Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models, where repeated sampling and tissue collection is possible. Here, we show that SARS-CoV-2 causes respiratory disease in infected rhesus macaques, with disease lasting 8-16 days…
Taken together, the rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures.
Hospitals “are themselves becoming sources of [coronavirus] infection,” with Covid-19 patients transmitting infections to other patients, one doctor said.
We are working with governments to determine where demand is and where it is most urgent. This is a tool designed to gather data as efficiently as possible to assist in distribution efforts.
We analyzed the movements of hundreds of millions of people to show why the most extensive travel restrictions to stop an outbreak in human history haven’t been enough.
The alert system signals the start of a new phase in NZ’s battle against Covid-19. Siouxsie Wiles explains what it means, with illustrations by Toby Morris.
What the Next 18 Months Can Look Like, if Leaders Buy Us Time
Still, the most severe cases of Covid-19, and the highest rates of death, are among the elderly — up to 27% of people 85 and older have died.
A key public health priority during the emergence of a novel pathogen is estimating clinical severity, which requires properly adjusting for the case ascertainment rate and the delay between symptoms onset and death. Using public and published information, we estimate that the overall symptomatic case fatality risk (the probability of dying after developing symptoms) of COVID-19 in Wuhan was 1.4% (0.9–2.1%)…
Compared to those aged 30–59 years, those aged below 30 and above 59 years were 0.6 (0.3–1.1) and 5.1 (4.2–6.1) times more likely to die after developing symptoms. The risk of symptomatic infection increased with age (for example, at ~4% per year among adults aged 30–60 years).
New C.D.C. data showed that nearly 40 percent of patients sick enough to be hospitalized were aged 20 to 54. But the risk of dying was significantly higher in older people.
This phylogeny shows evolutionary relationships of hCoV-19 (or SARS-CoV-2) viruses from the ongoing novel coronavirus COVID-19 pandemic. This phylogeny shows an initial emergence in Wuhan, China, in Nov-Dec 2019 followed by sustained human-to-human transmission leading to sampled infections.