Structure of the Fanconi anaemia monoubiquitin ligase complex

The structure of the multiprotein Fanconi anaemia core complex, determined using cryo-electron microscopy and mass spectrometry, shows that the complex adopts an extended asymmetric structure and highlights the structural and functional asymmetry of the RING finger domains.

AlphaStar: Grandmaster level in StarCraft II using multi-agent reinforcement learning

AlphaStar is the first AI to reach the top league of a widely popular esport without any game restrictions. This January, a preliminary version of AlphaStar challenged two of the world’s top players in StarCraft II, one of the most enduring and popular real-time strategy video games of all time. Since then, we have taken on a much greater challenge: playing the full game at a Grandmaster level under professionally approved conditions.

A deep learning framework for neuroscience

In artificial neural networks, the three components specified by design are the objective functions, the learning rules and the architectures. With the growing success of deep learning, which utilizes brain-inspired architectures, these three designed components have increasingly become central to how we model, engineer and optimize complex artificial learning systems. Here we argue that a greater focus on these components would also benefit systems neuroscience.

The night gardeners: Immune cells rewire, repair brain while we sleep

Science tells us that a lot of good things happen in our brains while we sleep—learning and memories are consolidated and waste is removed, among other things. New research shows for the first time that important immune cells called microglia—which play an important role in reorganizing the connections between nerve cells, fighting infections, and repairing damage—are also primarily active while we sleep.